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  1. #1
    Pumping Iron
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    Default To σκόρδο ρίχνει την τεστοστερόνη.

    Reproductive Biology and

    Chronic crude garlic-feeding modified adult male rat testicular
    markers: mechanisms of action
    Imen Hammami1,2, Souheila Amara2, Mohamed Benahmed2, Mich#232;le V El
    May1 and Claire Mauduit*3

    Background: Garlic or Allium sativum (As) shows therapeutic effects such as reduction of blood
    pressure or hypercholesterolemia but side-effects on reproductive functions remain poorly
    investigated. Because of garlic's chemical complexity, the processing methods and yield in
    preparations differ in efficacy and safety. In this context, we clarify the mechanisms of action of
    crushed crude garlic on testicular markers.
    Methods: During one month of treatment, 24 male rats were fed 5%, 10% and 15% crude garlic.
    Results: We showed that crude garlic-feeding induced apoptosis in testicular germ cells
    (spermatocytes and spermatids). This cell death process was characterized by increased levels of
    active CASP3 but not CASP6. Expression of the caspase inhibitors BIRC3 and BIRC2 was increased
    at all doses of As while expression of XIAP and BIRC5 was unchanged. Moreover, expression of
    the IAP inhibitor DIABLO was increased at doses 10% and 15% of As. The germ cell death process
    induced by As might be related to a decrease in testosterone production because of the reduced
    expression of steroidogenic enzymes (Star, Cyp11a, Hsd3b5 and Hsd17b). Evaluation of Sertoli
    markers showed that TUBB3 and GSTA2 expression was unchanged. In contrast, AMH, RHOX5
    and CDKN1B expression was decreased while GATA4 expression was increased.
    Conclusion: In summary, we showed that feeding with crude garlic inhibited Leydig steroidogenic
    enzyme expression and Sertoli cell markers. These alterations might induce apoptosis in testicular
    germ cells.

    Το σκόρδο επηρεάζει σε κυτταρικό επίπεδο την έκκριση τεστοστερόνης.
    Τουλάχιστον αυτό συμβαίνει στα κύτταρα των ζώων που χρησιμοποιήθηκαν για την έρευνα. Επειδή η φυσιολογία των αντίστοιχων κυττάρων με τα ανθρώπινα είναι ίδια , υπάρχει μεγάλη πιθανότητα το ίδιο να συμβαίνει και στον άνθρωπο.


  2. #2
    Senior Bodybuilder sok's Avatar
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    Ρέθυμνο, Greece.


    Ε το σκόρδο!:D
    Ευχαριστούμε για την έρευνα![:-thumbu]

  3. #3
    Advanced Bodybuilder
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    mytilini, building, Greece.


    ριχνει την πιεση, ριχνει την τεστοστερονη....... ε καλα ανεβαζει τιποτα ??? :)

  4. #4
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    Originally posted by spenzasx

    ριχνει την πιεση, ριχνει την τεστοστερονη....... ε καλα ανεβαζει τιποτα ??? :)

    Ναι!ανεβαζει...την αποσταση αναμεσα στους ανθρωπους!!!! :D

  5. #5
    Bodybuilding Newbie
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    θα ελεγα πως ολο και κατι ανεβαζει.

    Αυτο ειναι αποσπασμα απο journal (Turk J Med Sci
    30 (2000) 557-561):

    Several studies have investigated the relationship
    between haemorheological parameters and VO2max and
    endurance performance. Ernst et al. (1985) tested
    athletes for maximal work output, and found that blood
    fluidity (quantified by a score taking into account four
    major determinants of blood viscosity - haematocrit,
    plasma viscosity, red cell deformability and red cell
    aggregation) correlates significantly with fitness: the
    fitter the athlete the more fluid his blood (7). It was
    stated that total peripheral resistance is composed of
    both vascular and viscous resistance, and a #210;rheological
    advantage#211; in athletes might contribute to better oxygen
    supply to the working musculature (7, 8).
    An increase in whole blood viscosity and plasma
    viscosity as an acute response to exercise has been shown
    by several studies (5, 16-19). Increased whole-blood
    viscosity may decrease oxygen and nutrient supply to
    working muscle tissues, and thus may reduce exercise
    performance (8, 17).
    Chien (1982) and Usami (1982) suggested that
    fibrinogen concentration has the greatest relative
    influence on plasma viscosity (20, 21). Martin et al.
    (1985) found a slight increase (3.7%) in fibrinogen levels
    after maximal exercise. They suggested that this smaller
    than expected rise in fibrinogen concentration has several
    rheological consequences that are advantageous for the
    exercising subject (16). However, increases in plasma
    viscosity (because of an increase in fibrinogen
    concentration) elevate whole-blood viscosity and decrease
    the flow, without enhancing oxygen transport (21).
    Letcher et al. (1981) proposed that a decrease in
    plasma viscosity in endurance-trained individuals at rest
    and during exercise will increase the efficiency of oxygen
    delivery (5). They found significantly lower plasma
    viscosity in a group of 13 subjects who ran 20-70
    miles/week when compared with 12 sedentary subjects.
    The difference was primarily due to a lower fibrinogen
    concentration in the runners.
    Increased fibrinolytic activity has been suggested as
    the mechanism of decreasing fibrinogen concentration at
    near pre-exercise levels during exercise-induced
    haemoconcentration (5, 6). It is well documented that
    fibrinolytic activity is markedly accelerated with exercise
    (22, 23, 24) and a decrease in fibrinogen subsequently
    results in lower plasma viscosity (16).
    Several studies have reported that garlic significantly
    enhances fibrinolytic activity in humans within a few
    hours of administration. Chutani et al. (1981) found that
    fibrinolytic activity increases about 72 % six hours after
    ingestion of raw garlic and 63 % six hours after ingestion
    of fried garlic, and that this increase was maintained up
    to 12 h (25). Jung et al. (1991) reported that 5h after
    the ingestion of garlic tablets there was a significant
    increase (86 %) in tissue plasminogen activator, which
    increases fibrinolytic activity. They also found a visible
    increase in vessel diameter and assumed that it resulted
    from vessel dilation. It was stated that the observed
    vasodilatation results in an increase in capillary skin
    perfusion (13). Their results are in accordance with the
    findings of Wolf et al. (1990), who detected a significant
    increase in conjunctival vessel diameters (arterioles and
    venules) five hours after ingestion of 900 mg garlic (26).
    The findings of this study revealed that garlic
    significantly increased the VO2max and endurance
    performance time of college endurance athletes 5 h after
    the administration of a single dose. A further increase in
    fibrinolytic activity in the resting state might have been
    responsible for the higher oxygen consumption and
    improved running performance during treadmill running
    tests of aerobic athletes.

  6. #6
    Bodybuilding Newbie
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    Άμα βάλεις στο google "garlic, testosterone" θα σου βγάλει έρευνες ότι αυξάνει την τεστοστερόνη. Μήπως το αποτέλεσμα οφείλεται στη δοσολογία; Όταν λέει 15% μήπως εννοεί ότι το σκόρδο ήταν το 15% της διατροφής των ποντικιών; Αν είναι έτσι μιλάμε για γιγαντιαία δόση σκόρδου.

    Ως γνωστόν το σκόρδο είναι καυστικό στο δέρμα και μπορεί ακόμη και να σκοτώσει σε τεράστιες δόσεις. Στα κύταρα των όρχεων θα κόλλαγε; :PP

  7. #7
    Junior Bodybuilder Polydamas's Avatar
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    Quote Originally Posted by jamvrsp View Post
    <blockquote id=quote>Quote:Originally posted by spenzasx

    ριχνει την πιεση, ριχνει την τεστοστερονη....... ε καλα ανεβαζει τιποτα ??? :)
    </blockquote id=quote>

    Ναι!ανεβαζει...την αποσταση αναμεσα στους ανθρωπους!!!! :D
    garlic..................................disconnecting people!!!!
    Αν καλόν έχη τις σώμα και ψυχήν κακήν,καλήν έχει ναυν και κυβερνήτην κακόν.
    Αθλιώτερον εστι μη υγιους σώματος υγιαν ψυχήν συνοικείν.

    Αν έχει κανείς όμορφο σώμα και ψυχή κακή, καλό έχει καράβι, μα κακό κυβερνήτη.
    Αθλιώτερο (όμως) είναι γερή ψυχή να μη συνοικεί σε γερό σώμα.


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