Η παρακατω ερευνα ειναι πολυ ενδιαφερουσα, 1ον γιατι ειναι μεγαλης διαρκειας (12 μηνες), 2ον γιατι ειναι σε γυναικες μετα την εμμηνοπαυση και 3ον γιατι μελετηθηκε η επιδραση οχι στον υπνο που ειναι το συνηθες αλλα στην απωλεια λιπους και την αυξηση μυικου ιστου.
Το αποτελεσμα, το group που επαιρνε μελατονινη καθε βραδυ (1 ή 3γρ), εχασε περισσοτερο σωματικο λιπος και ειχε οριακη αυξηση σε μυικο ιστο!
Η ερευνα:
Clin Endocrinol (Oxf). 2016 Mar;84(3):342-7. doi: 10.1111/cen.12942. Epub 2015 Oct 8.
Reduced fat mass and increased lean mass in response to 1 year of melatonin treatment in postmenopausal women: A randomized placebo-controlled trial.
Amstrup AK1, Sikjaer T1, Pedersen SB1,2, Heickendorff L3, Mosekilde L1, Rejnmark L1,2.
OBJECTIVE:
Apart from regulating the circadian rhythm, melatonin exerts a variety of actions in the living organism. Among these functions, melatonin is believed to have a positive effect on body weight and energy metabolism. So far, the evidence for this relies mainly on animal models. In this study, we aimed to determine the effects of melatonin on body composition, lipid and glucose metabolism in humans.
DESIGN/METHODS:
In a double-blind, placebo-controlled study, we randomized 81 postmenopausal women to 1 year of treatment with melatonin (1 or 3 mg nightly) or placebo. Body composition was measured by DXA. Measures were obtained at baseline and after 1 year of treatment along with leptin, adiponectin and insulin. Markers of glucose homeostasis were measured at the end of the study.
RESULTS:
In response to treatment, fat mass decreased in the melatonin group by 6·9% (95% CI: 1·4%; 12·4%, P = 0·02) compared to placebo. A borderline significant increase in lean mass of 5·2% was found in the melatonin group compared to placebo (3·3%, (IQR:-1·7; 6·2) vs -1·9%, (IQR: -5·7; 5·8), P = 0·08). After adjusting for BMI, lean mass increased by 2·6% (95% CI: 0·1; 5·0, P = 0·04) in the melatonin group. Changes in body weight and BMI did not differ between groups. Adiponectin increased borderline significantly by 21% in the melatonin group compared to placebo (P = 0·08). No significant changes were observed for leptin, insulin or markers of glucose homeostasis.
CONCLUSION:
Our results suggest a possibly beneficial effect of melatonin on body composition and lipid metabolism as 1 year of treatment reduces fat mass, increases lean mass and is associated with a trend towards an increase in adiponectin.
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